iSpy-LIFE is a global research network focused on understanding and combating Group A Streptococcus (Strep A) infections, a leading cause of preventable deaths worldwide. Strep A can cause a broad spectrum of illnesses, ranging from relatively mild conditions like strep throat to severe and life-threatening diseases.

The iSpy-LIFE team brings together an international group of leading experts with diverse specialisations. Our researchers are delving into the intricacies of how Strep A interacts with the human body, including the mechanisms of streptococcal pathogenesis. We are investigating the complex responses of our immune system, including B and T cell responses, mucosal immunity (the defences in our nose, throat, and gut), and the role of antibodies. Our team also explores the fields of glycol immunology (how sugars in our body affect infection) and immunogenetics (how our genes influence our susceptibility).

By integrating our expertise, iSpy-LIFE aims to unravel the complex interplay between Strep A and the human immune system, leading to the development of innovative approaches for preventing and treating these infections and reducing their global burden.